ICMLSC 2018, The 2nd International Conference on Machine Learning and Soft Computing, will take place in Phu Quoc Island, Vietnam, from February 2-4, 2018. ICMLSC 2018 is co-organized by the University of Science, Vietnam and Industrial University of Ho Chi Minh City. ICMLSC 2018 is a not-to-be-missed opportunity that distills the most current knowledge on a rapidly advancing discipline in one conference. Join key researchers and established professionals in the field of Machine Learning and Soft Computing as they assess the current state-of-the-art and roadmap crucial areas for future research. We aim to build an idea-trading platform for the purpose of encouraging researchers to participate in this event. The papers to be presented at ICMLSC 2018 address many grand challenges in modern engineering. The full papers to be presented will be peer-reviewed by expert reviewers including the whole Organising Committees members of ICMLSC 2018. We will be thankful for the contributions to ICMLSC 2018. We look forward to your participation and continued engagement at future ICMLSC conferences.